Edetate, sodium antioxidant

Antioxidant synergists These enhance the effect of antioxidants Edetic acid, sodium edetate... [Pg.202]

Preservatives Antimicrobial Benzalkonium chloride Benzyl alcohol Chlorhexidine Imidazolidinyl urea Phenol Potassium sorbate 1 Benzoic acid Bronopol Chlorocresol Paraben esters Phenoxyethanol Sorbic acid Antioxidants a-Tocopherol Ascorbic acid Ascorbyl palmitate Butylated hydroxyanisole Butylated hydroxytoluene Sodium ascorbate Sodium metabisulphite Chelating agents Citric acid Edetic acid... [Pg.545]

Sulfacetamide sodium undergoes degradation in aqueous solution by two routes, oxidation and hydrolysis. Ophthalmic solutions of this compound frequently contain sodium metabisuifite as an antioxidant to decrease the rate of development of the yellow color characteristic of degraded solutions. Davies and coworkers have shown that sodium metabisuifite accelerates the hydrolytic degradation of sulfacetamide to sulfanilamide, whereas sodium edetate does not influence the rate. [Pg.260]

Oxidation, in oral liquids, in practice is inhibited by removal of oxygen from water by boiling, reduction of headspace by completely filling of bottles, addition of a chelating agent (sodium edetate) for the removal of catalysing traces of metals and the addition of antioxidants, such as ascorbic acid (see Sect. 22.2.2). [Pg.92]

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