EDDA

Figure 2 Expression of pelD uidA fusion in strains L37 (open bars) and L37 cbsE-1 (filled bars) grown in (A) Tris medium supplemented with FeC13 (20 jiM) or EDDA and (B) intercellular fluids of healthy African violets, supplemented or not with FeC13 (20 fiM). OD at 600 nm of the samples was 1.5. GUS activity is expressed per OD units.

P 39] Protocol for single-run processing reservoirs of the 110 Caliper chip were filled with the following solutions [18] 0.10 M solutions of rac-citronellal and a synthesized aromatic aldehyde in methanol/water (80 20) and 0.12 M solutions of 1,3-dimethylbarbituric acid and Mel drum s acid in methanol/water (80 20) with 10% molar catalyst efhylenediamine diacetate (EDDA). 

Fig. 17. Plot of change in complex stability, Alog K, that occurs for the pairs of ligands THEEN and EN (O), and PDTA-amide and EDDA ( ), as a function of metal ion radius (20). The diagram shows how netural oxygen donors stabilize the complexes of large metal ions relative to small metal ions. Alog Ki for THEEN and EN, for example, is log Kx for the THEEN complex of the particular metal ions, minus log Kx for the EN complex. Data from Ref. (11).

The roundel again on the title page, and a quotation I know by heart because it appears, set small, in every book the Press has ever issued As the Edda tells it, in the land of the giants lived a man named Mundilfoeri and he had two children his daughter Sol was the sun, and his son Mani the moon. ... 

As the name implies, the first step of this domino process consists of a Knoevenagel condensation of an aldehyde or a ketone 2-742 with a 1,3-dicarbonyl compound 2-743 in the presence of catalytic amounts of a weak base such as ethylene diammonium diacetate (EDDA) or piperidinium acetate (Scheme 2.163). In the reaction, a 1,3-oxabutadiene 2-744 is formed as intermediate, which undergoes an inter- or an intramolecular hetero-Diels-Alder reaction either with an enol ether or an alkene to give a dihydropyran 2-745. 

In addition to aldehydes and a-diketones, a-ketoesters can also be used in the domino process, as shown by Tietze and coworkers [396]. Reaction of methyl pyruvate 2-791 with dimethylbarbituric acid (2-747) and the enol ether 2-792 in the presence of trimethyl orthoformate (TMOF) and a catalytic amount of EDDA gave the cycloadduct 2-793 in 84% yield (Scheme 2.176). 

The domino reaction of (IS)-2-808, Meldmm s acid (2-801) and enol ether 2-802b in the presence of EDDA, followed by treatment with K2C03/Me0H and a catalytic amount of Pd/C in methanol under a nitrogen atmosphere for 50 min and subsequently under a H2-atmosphere for 2 h at r.t. gave the benzoquinolizidine 2-809 with the correct stereochemistry at all stereogenic centers as in emetine (2-798) and tubulosine (2-799), together with two diastereomers (Scheme 2.180) [406]. Further manipulations of 2-808 led to emetine (2-798) and tubulosine (2-799). 

In the Nordic creation myth, which can be found at the beginning of the Edda, we encounter Ginnungagap, a timeless, yawning void. It contains a type of supreme god, Fimbultyr, who willed the formation of Niflheim in the north, a cold, inhospitable land of fog, ice and darkness, and in the south Muspelheim (with light and fire). Sparks from Muspelheim flew onto the ice of Niflheim. This caused life to emerge, and the ice giant Ymir and the huge cow Audhumbla were formed. 

Larrington C (translator) (1999) The Poetic Edda. Oxford University Press... 

Namely, the reaction of 2-thioxothiazolidin-4-one N-hexanoic acid (116) with 2,5-dimethyl-l-phenylpyrrol-3-carboxaldehyde (117) in methanol under the catalytic action of ethylenediamine diacetate (EDDA) yields 5-[(2,5-dimethyl-l-phenylpyrrol-3-yl)methylidene]-2-thioxothiazolidin-4-one N-hexanoic acid (118) in 79% yield. The hydroxamate derivative of 118 is prepared by reacting this compound with 0-(tetrahydro-2H-pyran-2-yl)hydroxylamine followed by treatment with p-toluenesulfonic acid in methanol to afford compound 121 in 60% yield. Esterification of compound 118 is carried out by using methyl iodide in acetonitrile in the presence of sodium carbonate to give compound 120. The 5-(cyclohexyl)methylidene analogue (119) is obtained in 42% yield by direct reaction of compound 116 with cyclohexanecar-boxaldehyde in methanol under the catalytic action of EDDA. 

Fig. 2.15 Plot of AS (J K- mol ) vs AK (cm moK ) for racemization and geometrical isomerization of a variety of octahedral metal complexes. Only a few entries are selected from the 27 reactions tabulated in Ref. 180. The deviation of (four) Cr(IlI) complexes represented by Cr(phen) + (3) from the linear plot (best fit for 23 complexes) may indicate that these recemize by twist, and not dissociative, mechanisms. Racemization of Cr(C204)3 -(l), Co(Ph2dtc)3(2), Cr(phen)3 (3), Ni(phen)f+(4). Geometrical isomerization of trans-Cr(C204)2(H20)2 (5), trans-Co(en)2(H20) +(6), (3-Co(edda)en+(7).

Other mixed donor ligands. The preparation of Cs[Co(edda)X2] (edda = ethylenediamine-iViV -diacetate. X = NO2 or N3 — ox) complexes has... 

During the early sixties Thompson and Loraas (77) reported the formation of mixed complexes of reasonable stability (log K 3.0—5.3) between lanthanide—HEDTA and ligands such as EDDA (N,N -ethylenediaminediacetic acid), HIMDA (N-hydroxyethyliminodiacetic acid) and IMDA (iminodiacetic acid). This observation together with the remarkably large formation constants (72) for the bis-EDDA complexes [log A2 =4.73 (La) 8.48 (Lu)] suggested a coordination number larger than six for the tripositive lanthanide ions in aqueous solution, in view of the fact that mixed chelates of the t5q>e M (HEDTA) (IMDA) axe not formed when M =Co(II), Ni(II) or Cd(II). 

---