Econazol, antimycotic

Because of their limited, activity, small spectmm, and side effects, the older topical antimycotics have generally been surpassed by newer antimycotic chemotherapeutic agents. These newer antimycotics for topical use iaclude the imida2ole derivatives clotrimazole, miconazole, econazole, isoconazole, sulconazole, fenticonazole, oxiconazole, bifonazole, butoconazole, ziaoconazole, tioconazole, and the triazole derivative, terconazole (Table 2) (5—7). The iatroduction of the azole derivatives represents a milestone ia the treatment of mycoses. 

Other imidazole derivatives include clotrimazole (Fig. 5.20B), miconazole (Fig. 5.20C) and econazole (Fig. 5.20D), all of which possess a broad antimycotic spectrum... 

Other imidazole derivatives include clotrimazole (Fig. 10.22B), miconazole (Fig. 10.22C) and econazole (Fig. 10.22D), all of which possess a broad antimycotic spectrum with some antibacterial activity and are used topically. Miconazole is used topically but can also be administered by intravenous or intrathecal injection in the treatment of severe systemic or meningeal fungal infections. Newer imidazoles are (a) ketoconazole (Fig. 10.22E),... 

Niemegeers CJE, Levron JC, Awouters F, Janssen PAJ. Inhibition and induction of microsomal enz5mes in tiie rat. A comparative study of four antimycotics miconazole, econazole, clotrimazole and ketoconazole. Arch IntPharmacodyn Ther (19SV) 251,26-38. 

Treatment of dermatophytoses is nowadays straightforward. The topical agents, including various imidazoles (econazole, tioconazole, isoconazole, bifonazole, etc.) are equally efficient and can be used in all forms of dermatophytosis except onychomycosis (due to lack of penetration). One daily application is considered adequate for 2-4 weeks. There is a tendency to use simultaneously systemic antimycotics, even in tinea corporis, when multiple lesions are present. 

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