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Ecological implications of genotoxic effects

Many heritable mutations are correlated with a reduced fitness, i.e. a reduced survival probability of the offspring of the mutant. The reduction in average fitness with the arrival of new mutations is called mutation load (Crow and Kimura, 1970). However, the more deleterious a mutation is, the sooner it will [Pg.249]

Ahnstrom, G. and Erixon, K. (1981) Measurements of strand breaks by alkaline denaturation and hydroxyapatite chromatography. In DNA Repair a Laboratory Manual of Research Procedures, Friedberg, E.C. and Hanawalt, P.C. (eds), vol. 1(B), pp. 403—41X. Marcel Dekker, New York. [Pg.251]

Al-Sabti, K. and Kurelec, B. (1985) Induction of chromosomal aberrations in the mussel Mytilus galloprovincialis watch. Bull. Environ. Contam. Toxicol, 35, 660-665. [Pg.251]

Durston, W.E.E., Yamasaki, Y. and Lee, F.D. (1973) Carcinogens are mutagens a simple test system combining liver homogenates for activation and bacteria for detection. Proc. Natl. Acad. Sci. USA, 70, 2281-2285. [Pg.251]

McCann, J. and Yamasakim, E. (1975) Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenecity test. Mutat. Res., 31, 347-364. [Pg.252]


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