Ecdysteroid antagonistic activity resveratrol

The plant-insect chemical interactions concerning the stilbenoids have just been reviewed [509] (-i-)-Ampelopsin B (806) and ct-viniferin (635) antagonized the action of 20-hydroxyecdysone [510] cw-miyabenol A (735), kobophenol B and cw-miyabenol C (663) showed competitive binding to ecdysteroid receptors [337] resveratrol (1) and oligomers (suffruticosols A-C, 589-591) also exhibited ecdysteroid antagonistic activity [297]. [Pg.605]

Sarker SD, Whiting P, Dinan L (1999) Identification and ecdysteroid antagonist activity of three resveratrol trimers (suffruticosols A, B and C) from Paeonia suffruticosa. Tetrahedron 55 513-524... [Pg.1943]

Dinan L. reported that three resveratrol trimers, suffruticosols A (100), B (101), C (102), and one monomer cis resveratrol from Paeonia suffruticosa are active as ecdysteroids (antagonists (EDso) 10-50 pM vs. 5xlO 8pM of 20-hydroxyecdyson), but inactive as agonists in the Drosophila melanogaster BII cell bioassay for ecdysteroids agonists/ antagonists [75]. [Pg.630]

Big Chemical Encyclopedia