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EC50

For the sample search on aquatic toxicity of atrazine, 1459 results were found. An excerpt on the daphnia acute aquatic toxicity tests (EC50. LC.50) is prc.scnted in Figure 5-33. [Pg.278]

FIGURE 1.15 Dose-response curves. Dose-response curve to an agonist that produces 80% of the system maximal response. The EC50 (concentration producing 40% response) is 1 pM, the EC25(20%,) is 0.5 pM and the ECg0 (64%) is 5 jiM. [Pg.17]

Replicate values of -1/Nlog EC50 s. 2Replicate EC5q values innM. [Pg.18]

Receptor density has disparate effects on the potency and maximal responses to agonists. The operational model predicts that the EC50 to an agonist will vary with receptor density according to the following relationship (see Section 3.13.3)... [Pg.85]

In terms of the operational model, the EC50 of a partial agonist can also be shown to approximate the KA. The response to an agonist [A] in terms of the operational model is given as... [Pg.97]

For Max partial agonist), Equation 5.22 shows that x is not considerably greater than unity. Under these circumstances, it can be approximated that (x + l)—> 1. Under these circumstances, the equation for EC50 for a partial agonist reduces to... [Pg.97]

From Equation 7.3, the observed EC50 for the agonist, in the presence of a concentration of allosteric antagonist [B] is given by... [Pg.144]

It can be seen that if it is assumed that the antagonism is competitive and a correction is applied according to Equation 10.5, then an error in the calculated KB, equal to the factor ((2 + ([A]/EC50)11)1 1 -1), will be applied to the estimate. [Pg.211]

Under ideal conditions, inhibition curves should be obtained by blockade of an EC50 concentration of agonist. [Pg.216]

The potency ratio of two agonists (ratio denoted as EC50/EC50) is... [Pg.219]


See other pages where EC50 is mentioned: [Pg.193]    [Pg.193]    [Pg.355]    [Pg.17]    [Pg.17]    [Pg.18]    [Pg.18]    [Pg.41]    [Pg.48]    [Pg.48]    [Pg.88]    [Pg.89]    [Pg.89]    [Pg.90]    [Pg.90]    [Pg.90]    [Pg.92]    [Pg.93]    [Pg.96]    [Pg.96]    [Pg.97]    [Pg.97]    [Pg.101]    [Pg.104]    [Pg.104]    [Pg.111]    [Pg.112]    [Pg.117]    [Pg.136]    [Pg.137]    [Pg.144]    [Pg.144]    [Pg.200]    [Pg.202]    [Pg.204]    [Pg.204]    [Pg.210]    [Pg.211]    [Pg.218]    [Pg.219]    [Pg.220]   
See also in sourсe #XX -- [ Pg.408 ]




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