Early Biochemical Changes

Sevitt has suggested that traumatic lipemia with rise in free fatty acids in particular, and less markedly of cholesterol, neutral fat, and phospholipids, may be considered as part of the general metabolic response to injury. Pulmonary fat embolism is found at necropsy in 90-100% of patients who have died shortly after fracture—possibly a protective trapping mechanism in that few fat emboli will reach the systemic circulation. 

Definite traces of heat-coagulable protein frequently are excreted, notably during the time of maximum nitrogen excretion (C21). 

It has been suggested that blood lost into the area of trauma maybe the source of the nitrogen lost (Dll), but the fact that the increased urinary nitrogen loss disappears at highish environmental temperature and also on a protein-free diet argues against this view, and further the introduction of blood of equivalent nitrogen content to that excreted in the urine over and above that which would have been normal on the diets used, did not lead to this scale of loss (C5, C27, M19). 

During the early stages of the generally depressed vitality following receipt of a moderate to serious wound at ordinary environmental temperature there may be a relative or absolute anuria (C21). This is less apparent at higher environmental temperatures (C40). 

Early Changes in Carbohydrate Metabolism and in the Tricarboxylic Acid Cycle 

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This indicates that early biochemical changes can be identified using Raman spectroscopy. 

Schumm, D. E., Morris, H. P., and Webb, T. E., 1974, Early biochemical changes in phytohemagglutinin-stimulated peripheral blood lymphocytes from normal and tumor-bearing rats, Eur. J. Cancer 10 107. 

J. Lei, F. Lapeyrie, N. Malajezuk, and J. Dexheimer, Infectivity of pine and eucalypt isolates of PisoUthus tinctorius (Pers.) Coker Couch on roots of Eucalyptus iiro-phylla S, T, Blake in vitro 11. Ultrastruetural and biochemical changes at the early stage of myeorrhiza formation. New Phytol. II6 5 (1990). 

Yusupova F.D. Voprosy gigieny truda i ranniye kliniko-funktsional nye i biokhimicheskiye izmenyeniya kozhi pri vozdeystvii nekotoiykh pestitsidov (Questions of Workplace Health and Safety and Early Clinical, Functional, and Biochemical Changes in the Skin Affected by Some Pesticides Dis.. ..Candidate of Medical Sciences. Tashkent, 1988. 222 pp. 

Raman Spectroscopy for Early Cancer Detection, Diagnosis and Elucidation of Disease-Specific Biochemical Changes... 

Since chromatin condensation is an early morphological event in apoptosis, early attention was focused on the biochemical changes that bring this about. Chromatin condensation is accompanied by fragmentation of the chromatin into an easily diag-... 

Barclay, L. L., et al., 1981b. The string test an early behavioral change in thiamine deficiency. Pharmacol Biochem Behav. 14, 153-157. 

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