Early and Late Asthmatic Responses Role of IgE

The role of IgE antibodies in the initiation of the allergic cascade is well established (312,313) and is characterized by a biphasic response involving an immediate or early allergic response (EAR) and a late phase allergic response (EAR) (314) (Fig. 9). 

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Allergen-specific IgH-mediated FceRI receptor aggr tion results in cell exoc tosis and mediator release 

Mast ccll/l asophila sensili/ed with allergen-specific IgE via FceRI 

Major basic protein Eosinophil cationic protein 

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