I.E. du Pont de Nemours and Company

The alcohol was obtained from PCR, Incorporated, or was prepared from hexafluoroacetone (E. I. du Pont de Nemours and Company), benzene, and aluminum chloride by the published procedure. 

ARTHUR E. HUMPHREY Chairman), Lehigh University KENNETH B. BISCHOFF, University of Delaware CHARLES BOTTOMLEY, E.I. du Pont de Nemours and Company, Inc. STUART E. BUILDER, Genentech, Inc. 

Potymer Products Department, E. I. du Pont de Nemours and Company,... 

Tetrahydrofuran from E. I. du Pont de Nemours and Company can be dried conveniently by adding to it lithium aluminum hydride in small portions until no further reaction (evolution of hydrogen) ensues. After the mixture has been stirred for a few minutes, most of the tetrahydrofuran is distilled from it with stirring (to prevent bumping) (Note 3), and collected in a receiver protected from moisture by a calcium chloride tube. 

The phthalide used by the submitters and by the checkers was a commercial product, obtained from E. I. du Pont de Nemours and Company, Wilmington, Delaware. This product is no longer available. Phthalide may be prepared in 82.5 per cent yields by hydrogenation of phthalic anhydride in benzene at 270° under 3000 lb. pressure in the presence of copper chromite 1 or, in yields of 61-71 per cent, from phthalimide according to the procedure given in Org. Syn. 16, 71 Coll. Vol. 2, 1943, 526. 

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