Duggar, Benjamin

In 1948, Benjamin M. Duggar (1872-1956), a professor at the University of Wisconsin and a consultant to Lederle, isolated chlortetracycline from Streptomyces aureofaciens. Chlortetracycline, also called aureomycin, was the first tetracycUne antibiotic and the first broad-spectrum antibiotic. Active against various organisms, aureomycin works by inhibiting protein synthesis. The discovery of the tetracychne ring system also enabled further development of other important antibiotics. Since that time more than a hundred molecules active against a wide range of bacteria have been discovered. 

In 1948, Benjamin M. Duggar (1872-1956), University of Wisconsin, isolated chlortetracycline (see below) from Sterptomyces aureofaciens. It... 

The tetracydines are derived from Streptomyces and have a broad spectrum of activity which includes rickettsial and chlamydial infections. The first tetracydine, chlortetracycline (Aureomydn) was discovered by Benjamin Duggar in 1948. They are characterised by 4-fused rings with a vast array of substitutions (Fig. 22.44). The commonly used tetracydines which bear the general stmcture below indude chlortetracy-dine (7-chlorotetracycline, Ri=Cl, R2=OH, R3=H, R4=H), tetracydine (Ri=H, R2=OH, R3=H, R4=CH3), and doxy-cyline (Ri=H, R2=H, R3=OH, R =CH3). 

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