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9-ds-retinoic add

Fig. 4.11. Principle of signal transduction by RXR heterodimers. The activated hormone can be made available to the RXR heterodimer in three different ways, a) The hormone (e.g. T3 hormone) is synthesized in endocrinal tissue and reaches the DNA-bound RXR-T3R heterodimer in the nucleus via passive transport, b) The active hormone is formed in the cytosol from an inactive apo-hormone (as for, e.g. 9-ds-retinoic add), c) The hormone is synthesized intracellularly. In aU three cases, the binding of the hormone-RXR-heterodimeric complex is the signal that induces transcription activation of the downstream genes. After Mangelsdorf and Evans, 1995. Fig. 4.11. Principle of signal transduction by RXR heterodimers. The activated hormone can be made available to the RXR heterodimer in three different ways, a) The hormone (e.g. T3 hormone) is synthesized in endocrinal tissue and reaches the DNA-bound RXR-T3R heterodimer in the nucleus via passive transport, b) The active hormone is formed in the cytosol from an inactive apo-hormone (as for, e.g. 9-ds-retinoic add), c) The hormone is synthesized intracellularly. In aU three cases, the binding of the hormone-RXR-heterodimeric complex is the signal that induces transcription activation of the downstream genes. After Mangelsdorf and Evans, 1995.
Achkar, C.C. Bentel, J.M. Boylan, J.F. Scher, H.I. Gudas, LJ. Miller, W.H., Jr. Differences in the pharmacokinetic properties of orally administered aU-trans-retinoic add and 9-ds-retinoic add in the plasma of nude mice. Drzig Metab.Dispos., 1994, 22, 451—458 (gradient LOD 0.5 ng/mL extracted metabolites, isotretinoin, tretinoin, vitamin A]... [Pg.1232]

Receptor fiir 9-ds retinoic acid, RXR 9-cis retinoic add. Terpenoids AGGTCA DR-1... [Pg.150]

See other pages where 9-ds-retinoic add is mentioned: [Pg.158]    [Pg.195]    [Pg.1223]    [Pg.158]    [Pg.195]    [Pg.1223]    [Pg.585]   
See also in sourсe #XX -- [ Pg.526 , Pg.527 ]



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