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Drugs from marine organisms

The steps in the development of anticancer drugs from (marine) organisms are schematically shown in Fig. 7. The most important step in the selection process is initial mass screening. The screening methods can either be simple, such as tumor cell line or enzymatic (e.g., topoisomerase inhibition, microtubule as-sembly/dissassembly) tests, or more complex, such as an animal tumor in vivo. [Pg.220]

Berlepsch, K. Drug from Marine Organisms. The Target of the Roche Research Institute of Marine Pharmacology in Australia. Naturwissenschaften 67, 338 (1980). [Pg.320]

Fig. 7. Steps in cancer drug development from marine organisms... Fig. 7. Steps in cancer drug development from marine organisms...
Keenamide A is another novel cytotoxic cyclic hexapeptide isolated from a marine mollusk (Pleurobranchus forskalii Fig. 5.2 Wesson and Hamann, 1996). Keenamide A exhibited significant activity against the P-388, A-549, MEL-20, and HT-29 tumor cell lines. New classes of anticancer drug candidates isolated from marine organisms have been shown to possess powerful cytotoxic activity against multiple tumor types. [Pg.85]

Macrolides are a group of compounds containing a macrocyclic lactone ring and up to 9 conjugated tram double bands. In recent years, new macrolides have been isolated from marine organisms, some of them reported as promising candidates for future drugs. [Pg.726]

Jha RK, Xu Z (2004) Biomedical Compounds from Marine Organisms. Mar Drugs 2 123... [Pg.501]

Gupta L, Talwar A et al (2007) Bis and tris indole alkaloids from marine organisms new leads for drug discovery. Curr Med Chem 14 1789-1803... [Pg.322]

Pallela, R., Yoon, N.-Y., and Kim, S.-K. (2010). Anti-photoaging and photoprotective compounds derived from marine organisms. Mar. Drugs 8,1189-1202. [Pg.296]

Kumar Jha, R. and Zi-rong, X. (2004) Biomedical compounds from marine organisms. Mar. Drugs, 2, 123-146. [Pg.54]

Siuda, J.F., DeBemardis, J.F., Cavestri, R.C. Gas chromatographic detection of naturally occurring halogenated compounds derived from marine organisms. Food-Drugs from the sea. Marine Technol. Soc. Proc. 1972 [Worthen, L.R. (ed.)]... [Pg.88]


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Drug organizations

Marine organisms

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