Drug Treatment of Parkinsons Disease

Parkinsonism is a clinical syndrome that comprises four main features bradykinesia (a slowness and poverty of movement), muscular rigidity (increased resistance of muscles to passive movement), resting tremor, which usually disappears during voluntary movement, and abnormalities in posture and gait. 

Most of these disorders are related to degenerative processes that are confined to the neuromelanin-pigmented nuclei of the basal ganglia (the substantia nigra), the locus coeruleus and parts of the dorsal vagal nucleus and reticular formation. While the cause of idiopathic Parkinsonism is unknown, neuroleptics, viral infections and metals such as manganese are 

Fundamentals of Psychopharmacology. Third Edition. By Brian E. Leonard 2003 John Wiley Sons, Ltd. ISBN 0 471 52178 7 

IDIOPATHIC PARKINSONISM MULTIPLE SYSTEM ATROPHY NEUROFIBRILLARY TANGLE TYPE e.g. INDUCED BY NEUROLEPTICS 

LEWY BODY DEMENTIA eg - OLIVOPONTO CEREBELLAR ATROPHY e.g. — PROGRESSIVE SUBNUCLEAR PALSY - TUMOURS 

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