Drug targeting effective

MJ Marion, JL DeRisi, HA Bennett, VR Iyer, MR Meyer, CJ Roberts, R Stoughton, J Burchard, D Slade, H Dai, DE Bassett Jr, LH Hartwell, PO Brown, SH Friend. Drug target validation and identification of secondary drug target effects using DNA microarrays. Nature Med 4 1293-1301, 1998. 

Drugs Targets Mechanisms Functional Side effects... 

Polymeric microparticles have been studied and developed for several years. Their contribution in the pharmacy field is of utmost importance in order to improve the efficiency of oral delivery of drugs. As drug carriers, polymer-based microparticles may avoid the early degradation of active molecules in undesirable sites of the gastrointestinal tract, mask unpleasant taste of drugs, reduce doses and side effects and improve bioavailability. Also, they allow the production of site-specific drug targeting, which consists of a suitable approach for the delivery of active molecules into desired tissues or cells in order to increase their efficiency. 

There are three main drug targets that are antagonized to prevent or treat acute and delayed CINV 5-HT3 receptors, dopamine type 2 receptors (D2), and NK-1 receptors. 5-HT3-receptor antagonists are the most effective agents for preventing... 

RES-Avoiding Liposomes. Since intravenously administered liposomes tend to accumulate in the RES, liposomal drugs work effectively when the target site is the RES. On the other hand, when the target site is not the RES, liposomal uptake by RES should be avoided. Liposomes that are not recognized by the RES have... 

---