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Drug substance solid-state physical change

In the following sections, the solid-state physicochemical characteristics of drug substances and their physical changes related to polymorphism, hydrates, amorphous form, and the effect of water will be discussed. [Pg.243]

Solid-state physical change of drug substances is one of the major concerns of pharmaceutical stability due to its potential effects on the drug dissolution rate and bioavailability. Closely related to the mechanism of solid-state chemical reactions [44, 45], the physical changes of crystalline dmg substances may include four steps as described in Fig. 12.4. [Pg.249]

See other pages where Drug substance solid-state physical change is mentioned: [Pg.175]    [Pg.242]    [Pg.612]    [Pg.371]    [Pg.104]    [Pg.244]    [Pg.27]    [Pg.574]    [Pg.575]    [Pg.653]    [Pg.532]    [Pg.313]    [Pg.434]    [Pg.194]    [Pg.199]    [Pg.84]    [Pg.252]    [Pg.197]    [Pg.250]    [Pg.323]    [Pg.500]    [Pg.40]    [Pg.242]    [Pg.243]    [Pg.246]    [Pg.254]    [Pg.257]    [Pg.217]    [Pg.242]    [Pg.487]    [Pg.17]    [Pg.830]   
See also in sourсe #XX -- [ Pg.249 , Pg.250 ]



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