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Drug substance solid-state characteristics polymorphism

Infrared (IR) absorption spectroscopy, especially measured by FTIR, is a powerful technique for the physical characterization of pharmaceutical solids.When the structural characteristics of a solid perturb the pattern of vibrational motion for a given molecule, these alterations can be used as a means to study the solid-state chemistry of the system. FTIR spectra often are used to evaluate the type of polymorphism that exists in a drug substance and can be very useful to study the water contained within hydrate species. Solid-state IR absorption spectra often are obtained on powdered solids through the combined use of FTIR and diffuse reflectance detection, and interpreted through conventional group frequency compilations. ... [Pg.60]

In the following sections, the solid-state physicochemical characteristics of drug substances and their physical changes related to polymorphism, hydrates, amorphous form, and the effect of water will be discussed. [Pg.243]

See other pages where Drug substance solid-state characteristics polymorphism is mentioned: [Pg.649]    [Pg.461]    [Pg.612]    [Pg.484]    [Pg.586]    [Pg.653]    [Pg.527]    [Pg.96]    [Pg.244]    [Pg.250]    [Pg.360]    [Pg.493]    [Pg.244]    [Pg.251]    [Pg.12]    [Pg.208]   
See also in sourсe #XX -- [ Pg.244 ]



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Drug substance solid-state characteristics

Drug substances

Drugs solid state

Drugs, polymorphism

Polymorphic drugs

Polymorphism, drug-substance

Solid polymorphs

State characteristics

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