Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Drug solubility enhancement, conventional

Florence (1983) provide a comprehensive reference for the use of surfactants in drug formulation development. The treatment by Florence (1981) of drug solubilization in surfactant systems is more focused on the question at hand and provides a clear description of surfactant behavior and solubilization in conventional hydrocarbon-based surfactants, especially nonionic surfactants. This chapter will discuss the conventional surfactant micelles in general as well as update the reader on recent practical/commercial solubilization applications utilizing surfactants. Other uses of surfactants as wetting agents, emulsiLers, and surface modiLers, and for other pharmaceutical applications are nc emphasized. Readers can refer to other chapters in this book for details on these uses of surfactant Polymeric surfactant micelles will be discussed in Chapter 13, Micellization and Drug Solubility Enhancement Part II Polymeric Micelles. [Pg.257]

FIGURE 18.1 Advantages of a solid dispersion formulation, as compared to conventional capsule or tablet formulations, for enhancing dissolution rate, and consequent bioavailability of poorly water-soluble drugs. (From Serajuddin A. T. M. 19991 Pharm ScB8 1058-1066. With permission.)... [Pg.500]

See other pages where Drug solubility enhancement, conventional is mentioned: [Pg.90]    [Pg.543]    [Pg.781]    [Pg.3844]    [Pg.370]    [Pg.338]    [Pg.1]    [Pg.203]    [Pg.436]    [Pg.284]    [Pg.117]    [Pg.48]    [Pg.83]    [Pg.500]    [Pg.501]    [Pg.502]    [Pg.514]    [Pg.515]    [Pg.599]    [Pg.1331]    [Pg.300]    [Pg.693]    [Pg.455]    [Pg.693]    [Pg.1327]    [Pg.189]    [Pg.359]    [Pg.450]    [Pg.275]    [Pg.50]    [Pg.114]    [Pg.74]    [Pg.261]    [Pg.1116]    [Pg.1234]    [Pg.352]    [Pg.2274]    [Pg.464]    [Pg.215]    [Pg.215]    [Pg.6361]    [Pg.157]    [Pg.374]    [Pg.579]    [Pg.624]    [Pg.92]    [Pg.360]    [Pg.583]   


SEARCH



Drug solubility

Drugs Soluble

Enhanced solubility

Enhancement drugs

Solubility enhancement

Solubility enhancers

© 2024 chempedia.info