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Drug polyion complex micelles

The B block may consist of a water-soluble polymer, for example, poly(aspartic acid) P(Asp), that is rendered hydrophobic by the chemical conjugation of a hydrophobic drug (Yokoyama et al., 1992, 1993, 1996 Nakanishi et al., 2001), or is formed through the association of two oppositely changed polyions (polyion complex micelles) (Hatada etal., 1995,1998 Kataoka etal., 1996). Drugs used to couple the B block include cyclophosphamide, doxorubicin, cisplatin, pyrene, and iodine derivative of benzoic acid (Kwon and Kataoka, 1995 Trubetskoy et al., 1997 Yu etal., 1998). [Pg.310]

Recently diblock copolymers of PEG and ionic segments were prepared by atom-transfer radical polymerization of methacrylic aminoester using a monofunctionalized PEG macroinitiator and then subsequent quaternization. Like others [60] these polymers form so called polyion complex micelles by electrostatic interaction with oppositely charged molecules (e.g. drugs, oligonucleotides), where the PEG block acts as a steric stabilizer [67]. [Pg.14]

Yuan J, Luo Y, Gao Q (2011) Self-assembled polyion complex micelles for sustained release of hydrophilic drug. J Microencaps 28(2) 93-98... [Pg.258]

Lei G, Yanfeng M, Guiying L et al (2011) Self-assembled nanoparticles from thermo-sensitive polyion complex micelles for controlled drug release. Chem Eng J 174(1) 199-205... [Pg.258]

Y. Luo, X. Yao, J. Yuan, T. Ding, and Q. Gao, Preparation and drug-controlled release of polyion complex micelles as drug delivery systems. Coll. Surf. B Biointerfaces, 68,218-224, 2009. [Pg.309]

Li YM, Zhou Y, De B, Li LB (2014) Folate-modified pluronic-polyethylenimine and cholic acid polyion complex micelles as targeted drug delivery system for paclitaxel. J Microencapsul 31 805-814. doi 10.3109/02652048.2014.940010... [Pg.84]

Figure 4.1. Conventional PM (a) drug-conjugated PM (b) and PICM with the polyionic block consisting of cationic polymer (c) or polynu-cleic acid (antisense oligonucleotides (AON) or small interfering RNA (siRNA)) (d and e). In d and e, the core forming agent is either linear or branched cationic polymer, respectively. Polymer-metal complex micelles formed via the ligand substitution reaction where M and Y are the metal and the ligand, respectively (f). Figure 4.1. Conventional PM (a) drug-conjugated PM (b) and PICM with the polyionic block consisting of cationic polymer (c) or polynu-cleic acid (antisense oligonucleotides (AON) or small interfering RNA (siRNA)) (d and e). In d and e, the core forming agent is either linear or branched cationic polymer, respectively. Polymer-metal complex micelles formed via the ligand substitution reaction where M and Y are the metal and the ligand, respectively (f).
Synthesis and self-assembly in solution 2003 [41] and on soUd surfaces theories and computer simulations AB and ABA block copolymers micellar architectures co-micellization colloidal nanostructures controlled drug deUvery polyion micellar complexes metal nanopaiticles surface modification... [Pg.35]

See other pages where Drug polyion complex micelles is mentioned: [Pg.241]    [Pg.1270]    [Pg.1090]    [Pg.10]    [Pg.169]    [Pg.170]    [Pg.215]    [Pg.922]    [Pg.309]    [Pg.54]    [Pg.194]    [Pg.195]    [Pg.83]    [Pg.217]    [Pg.114]    [Pg.116]    [Pg.102]    [Pg.1274]    [Pg.284]    [Pg.173]    [Pg.88]    [Pg.88]    [Pg.241]    [Pg.108]    [Pg.182]   
See also in sourсe #XX -- [ Pg.88 , Pg.89 , Pg.90 , Pg.91 , Pg.92 , Pg.93 , Pg.94 ]

See also in sourсe #XX -- [ Pg.88 , Pg.89 , Pg.90 , Pg.91 , Pg.92 , Pg.93 , Pg.94 ]



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Complex polyion

Drug complex

Drug complexity

Polyion complex micelles

Polyion micelle

Polyion-complexation

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