Roxithromycin drug interactions

Another potential for drug interaction of roxithromycin may involve changes in binding of drugs to plasma proteins [26, 39]. In in vitro binding experiments, Zini et al. [26] found that disopyramide displaced roxithromycin and increased the free concentration of roxithromycin. The magnitude of the increase was not reported. Similar results were not seen with lidocaine or prednisolone [26]. Thus, the clinical significance of this interaction is unknown. 

Petri, R, and Mazzei, T. (1987). Pharmacokinetics of roxithromycin in renal and hepatic failure and drug interactions. J. Antimicrob. Chemother. 20 (Suppl. B), 107-112. 

Interacting drug Azithromycin Clarithromycin Erythromycin Roxithromycin Reference... 

Ghose K, Ashton J, Rdian A. Possible interaction of roxithromycin with wai rin updated rev ie w of ADR reports. Clm Drug Invest (1995) 10,302-9. 

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