Drug-induced cognitive impairment

Another aspect of radial maze performance is the use of positive motivation (food reward), in contrast to the aversive motivations maintaining the passive avoidance and Morris maze procedures. Data suggesting drug-induced cognitive impairment are more convincing if the impairments span the different motivational systems maintaining the behaviors. 

Moore, A.R. O-Keeffe, S.T. Drug-induced cognitive impairment in the elderly. Drugs Aging 1999, 75 (1), 15-28. 

Behavioral Assessment of Drug-Induced Cognitive Impairment. 104... 

Putten, rediscovered drug-induced dysphoria, which was noted to be associated with neurological effects, especially akathisia2 (Van Putten 1974, 1975). This was later labelled as akinetic depression (Van Putten May 1978). In the 1990s the term neuroleptic-induced deficit syndrome was coined to describe affective and cognitive impairment (Lader 1994) and drug-induced dysphoria was revisited (Hollister 1992 King, Burke, Lucas 1995). 

Common adverse drug-related effects are hip fractures, cognitive impairment, and neuroleptic-induced parkinsonism. 

Neurotoxicity is an important adverse health effect not only of hundreds of environmental contaminants and occupational chemicals but also of several pharmaceutical drugs. Indeed, several drugs are known to induce neurological complications such as cognitive impairment, cerebellar syndromes, or neuromuscular disorders.5-56 Most chemotherapeutic drugs induce neuropathies,57 while a wide array of pharmaceuticals have been associated with headaches.58... 

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