Drug—hormone interactions

PXR in Adrenal Steroid Homeostasis and Drug-Hormone Interactions... 

P. Pavek, G. Merino, E. Wagenaar, E. Bolscher, M. Novotna, J.W. Jonker, and A.H. Schinkel. Human breast cancer resistance protein Interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-l-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine. J Pharmacol Exp Ther. 312 144—152... 

The term drug-drug interaction is also used, to make the distinction from drug-food interactions, and interaction with endogenous transmitters and hormones. 

The fit may be unsatisfactory because only part of the drug is interacting with the receptor. This situation applies particularly to large drug molecules (e.g. peptide hormones), for which selective pruning of unused parts of the stracture may produce simpler compounds without loss of affinity ... 

Because of certain proprietary considerations, a protein other than the ALS enzyme will be used to demonstrate how molecular modeling techniques can be applied to the design of crop protection chemicals. Human serum prealbumin has been used by Blaney, et al (15) to model drug-receptor interactions. Its function is to transport the hormone thyroxin. The binding site for thyroxin will... 

List classes of drugs that interact (interfere) with thyroid hormones therapy. 

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