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Drug distribution AIDS drugs

Oprea TI. Property distributions of drug-related chemical databases. / Comput-Aided Mol Des 2000 14 251-264.55. [Pg.207]

Oprea, T. L. Property distribution of drug-related chemical databases. J. Comput.-Aided Mol. Des. 2000, 14, 251-254. [Pg.51]

In 1996, Congress passed the Drug-Induced Rape Prevention and Punishment Act of 1996, which increased the federal penalties for those who used any controlled substance to aid them in sexual assault. This law makes it a punishable crime to give someone a controlled substance without that person s knowledge of it and with the intent to commit a violent crime against that person. It also includes stiffer penalties for those who possess or distribute this drug. [Pg.70]

By the time of the protest at its headquarters, the FDA had already begun to change the drug approval process in an effort to shorten review times. The primary anti-AIDS drug AZT (Zidovudine) was distributed to more than 4,000 patients in 1986 and gained marketing approval after just 107 days of FDA... [Pg.31]

Drug distribution in such sites or compartments is a complex process that depends on the systemic circulation concentration and subsequent passage across single cell endothelial or epithelial membranes with specialized physical and molecular barrier functionality. For certain orally administered AIDS medications (e.g., zidovudine and didanosine), oral absorption is limited because of poor absorption from the G1 tract, enzymatic biotransformation in the intestinal epithelium, or first-pass effects (Sinko et al., 1995, 1997). For other AIDS drugs (e.g., protease inhibitors), oral absorption may be complete however, drug distribution into the brain is limited by drug efflux proteins, which promiscuously interact and translocate lipophilic substrates back into blood as they diffuse into the BBB endothelium (Edwards et al., 2005 Kim et al., 1998). [Pg.115]

Many patients in the tropics have diseases that are familiar to Western-trained physicians, but it is the epidemiology that is often different. Comparing the AIDS populations in Los Angeles and Eastern Africa is an obvious example. Different practices in antiviral therapy prescription, distribution, and drug pricing thus emerge in the two environments. [Pg.483]

A typical drug as administered to a patient may be in the form of a tablet, a capsule, or a solution for injection and it contains not only the active ingredient, but also additional substances that serve to promote the stability of the drug and aid in its reproducible dissolution and/or distribution. This section addresses the manufacture of the active ingredients. [Pg.1002]


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See also in sourсe #XX -- [ Pg.114 , Pg.115 , Pg.116 , Pg.117 , Pg.118 , Pg.119 , Pg.120 , Pg.121 ]




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