Drug disposition, role

Stanley LA, Horsburgh BC, Ross J et al (2006) PXR and CAR nuclear receptors which play a pivotal role in drug disposition and chemical toxicity. Drug Metab Rev 38 515-597... 

Y Tanigawara. Role of p-glycoprotein in drug disposition. Ther Drug Monitor 22 137-140, 2000. 

The role of other ABC-efHux transporters (ATP-binding cassette transporters) such as MRPs and BCRP was also intensively investigated over the past decade. However, most studies investigating the importance of ABC transporters for drug disposition were performed with different cell lines and animal models. In comparison to P-glycoprotein, only limited human data are available about the role of ABC transporters on drug disposition. In this chapter mainly human data will be discussed. For more detailed description and in vitro data about MRPs see Section 15.3. 

Jedlitschky, G., Hoffmann, U. and Kroemer, H.K. (2006) Structure and function of the MRP2 (ABCC2) protein and its role in drug disposition. Expert Opinion on Drug Metabolism and Toxicology, 2, 351-366. 

Multidrug Resistance Proteins and Drug Transport 346 Role of P-Glycoprotein for Drug Disposition 349 Vectorial Drug Transport 352 References 355... 

Fig. 5. Selection of candidate genes for selection in a either a study examining the role of pharmacogenomics in drug disposition and/or action or alternatively, use as a chnical tool to individualize drug therapy. Those genes prioritized for inclusion should he those shown to contribute markedly to drug pharmacokinetics and/or dynamics.

You G. The role of organic ion transporters in drug disposition an update. Curr Drug Metab. 2004 5 ... 

The goal of this review is to summarize the current state of knowledge in the area of pharmacogenetics of human transporters known to be involved in drug disposition. The molecular, biochemical, and physiological role of each transporter will be systematically outlined (Table 1) as well as the functional relevance of genetic polymorphisms in such transporters (Tables 2 and 3, www.vanderbilt.edu/kimlab). 

The Role of P-Glycoprotein in Drug Disposition Significance to Drug Development... 

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