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Drug discovery stages lead compound

At the drug discovery stage, lead compounds are often prepared as DMSO solutions. The intrinsic chemical stability of the drug molecule in solution under different stress conditions is the main focus of the stability profiling of drug candidates. Candidates with poor chemical stability can be easily identified while their physical... [Pg.242]

In the drug discovery stage, most drug metabolite profiling studies are conducted with nonradiolabeled lead compounds by using LC/UV/MS... [Pg.369]

One of the driving forces to apply combinatorial chemistry in drug discovery is to accelerate lead discovery and preclinical research in order to find the next drug. It is important that these combinatorial library compounds are as pure as possible when performing lead discovery screening. At this stage,... [Pg.60]

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Drugs lead compound

Lead compounds

Lead discovery