Mimetics drug discovery

Saragovi, H. et al. (1992). Loops and secondary structure mimetics development and applications in basic science and rational drug discovery. Bio j Technology 10, 1131-111. 

The power of the Passerini and Ugi reactions in constructing polyfunctional molecules has been well appreciated since the early studies. The classical Passerini and Ugi reactions afford a-acyloxy carboxamides and a-acylamino amides respectively, that can be easily manipulated by post-condensation reactions, generating molecular diversity for drug discovery and natural product synthesis [22], This strategy has been widely applied to the synthesis of natural peptides and open-chain peptide mimetics covered in this section. 

In a structure-based drug-discovery programme in the field of influenza virus neuraminidase inhibitors, researchers at BioCryst Pharmaceuticals discovered aminocarbafuranose sialyl mimetic 89 as a very potent candidate against influenza A and B viruses [17]. To arrive at this highly substituted compound in a non-racemic format, the viable route of Scheme 14 was executed. 

Nielsen, L. L. 2005. Incretin mimetics and DPP-IV inhibitors for the treatment of type 2 diabetes. Drug Discovery Today, 10,703-710. 

Ernst B, Kolb HC, Schwardt O (2006) Carbohydrate Mimetics in Drug Discovery. In Levy DE, Fiigedi P (eds) The Organic Chemistry of Sugars. CRC Press, Boca Raton, FL, p 803... 

F., Moehle, K., and Obrecht, D. (2008) The design, structures and therapeutic potential of protein epitope mimetics. Drug Discovery Today, 13, 944-951. 

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