Drug development strategies for

Dykens, J.A. (2007) RedOx Targets Enzyme Systems and Drug Development Strategies for Mitochondrial Dysfrmction, in Comprehensive Medicinal Chemistry II (eds D.J. Triggle and J.B. Taylor), Elsevier, Oxford, pp. 1053-1087. 

Steele, V.E. et al.. Cancer chemoprevention drug development strategies for resveratrol, Pharm. Biol, 36,1,1998. 

Natural reinforcers and drugs of abuse use similar circuits 912 The neuronal circuitry underlying drug craving has been intensely studied to develop strategies for preventing relapse 912... 

Fillet, M., Hubert, P., Crommen, J. Method development strategies for the enantiosep-aration of drugs by capillary electrophoresis using cyclodextrins as chiral additives. Electrophoresis 1998, 19, 2834—2840. 

The approaches for developing strategies for the delivery of drugs to the brain are shown in groups in the scheme in Figure 2.6. Pharmacological-based and physiological-based methods... 

Jemal M, Xia YQ. LC-MS development strategies for quantitative bioanalysis. Current Drug Metabolism 7, 491-502, 2006. 

The BCS paradigm can be used to develop strategies for enhancing drug solubility and/or permeability (Tables 8 and 9). Solubility enhancement may involve only... 

Since the protein target and the chemical modulator are unknown, for this drug development strategy methodologies are required that lead to structurally complex and diverse small molecules covering a broad region of the so-called chemical space [2, 6]. This is one of the main focuses of diversity-oriented... 

The system is well used and is now an integral part of the development strategy for tablet formulation. To date, it has successfully generated formulations for more than 40 active drugs. In many cases, the initial formulations have been acknowledged as being on a par with those developed by expert formulators. Consequently, the formulation optimization routine is now considered redundant and is used very rarely. 

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