Drug development current approaches

The three standard drugs used in the treatment of tuberculosis were streptomycin (considered above), -aminosalicylic acid (PAS) and isoniazid (isonicotinylhydrazide, INH synonym, isonicotinic acid hydrazine, INAH). The tubercle bacillus rapidly becomes resistant to streptomycin, and the role of PAS was mainly that of preventing this development of resistance. The current approach is to treat tuberculosis in two phases an initial phase where a combination of three dmgs is used to reduce the bacterial level as rapidly as possible, and a continuation phase in which a combination of... 

This volume gives an overview of the current status and an outlook to future more reliable predictive approaches. It is subdivided in five sections dealing with studies of membrane permeability and oral absorption, drug dissolution and solubility, the role of transporters and metabolism in oral absorption, computational approaches to drug absorption and bioavailability, and finally with certain drug development issues. 

Talevi A. Bellera C.L. Di Ianni M. Duchowicz P.R. Bruno-Blanch L.E. Castro E.A. An Integrated drug development approach applying topological descriptors. Current Computer-Aided Drug Design, 2012, 8 (3), 172-181. 

Anderson, M.E., Al-Khatib, S.M., Roden, D.M., and Califf, R.M., Cardiac repolarization current knowledge, criticl gaps and new approaches to drug development and patient management, Am. Heart., 144, 769-781, 2002. 

LTC4 and LTD4 are potent bronchoconstrictors and are recognized as the primary components of the slow-reacting substance of anaphylaxis (SRS-A) that is secreted in asthma and anaphylaxis. There are four current approaches to antileukotriene drug development 5-LOX enzyme inhibitors, leukotriene-receptor antagonists, inhibitors of FLAP, and phospholipase A2 inhibitors. 

Current Computational Methods to Estimate Drug Development Parameters for Use in Drug Discovery A Zero Infrastructure Approach. 

Kubinyi H, Combinatorial and computational approaches in structure-based drug design, Current Opinion in Drug Discovery and Development, 1 16-27, 1998. 

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