Drug design through

Kresge, A. J. (1987), Unusual reactivity of prostacyclin Rational drug design through physical organic chemistry, . Chem. Res., 20, 364-370. 

FIGURE 8.2 Examples of drug design through hybridization combination of two structural types to produce a unique chemical entity. (A) Design of ICS 205-903 [2], (B) Compound with vasodilating and beta-blocking properties [3]. 

Wlodawer, A. Rational approach to AIDS drug design through structural biology. Annu. Rev. Med. 2002, 53, 595-614. 

The first synthetic oestrogen traws-diethylstilbesterol came into existence by applying the principle of drug-design through disjunction Ifom oestradioE. Explain. 

The development of ganglionic block agent is exclusively based on the principle of mixed molecular" as drug design through conjunction. 

Also in the 1980s, structure-based drug design (SBDD) underwent a similar cycle. Early proponents oversold what could be achieved through SBDD, thereby causing pharmaceutical companies to reconsider their investments when they discovered that SBDD too was no panacea for filling the drug discovery cornucopia with choice molecules for development. Nevertheless, SBDD was an important advance. 

Physiologically based pharmacokinetic models provide a format to analyze relationships between model parameters and physicochemical properties for a series of drug analogues. Quantitative structure-pharmacokinetic relationships based on PB-PK model parameters have been pursued [12,13] and may ultimately prove useful in the drug development process. In this venue, such relationships, through predictions of tissue distribution, could expedite drug design and discovery. 

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