Drug design, reactivity index

The reactivity index is as well popular in pharmaceutical and drug applications. In particular, one problem of drug design is that one has to synthesize and screen thousands, sometimes millions, of candidate chemicals in developing one successful drug. There was a very successful study with reactivity index long back on human immunodeficiency virus (HIV) [95]. The cyclin-dependent kinases (CDKs) are a class of enzymes involved in the eukaryotic cell-cycle regulation. 

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