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Polyanhydrides drug delivery systems

Historically, polyanhydrides were synthesized for engineering materials. Because of their hydrolytical instability, these polyanhydrides have never been commercialized for engineering purposes. This instability has a beneficial aspect in drug delivery systems since the implant incorporated with an active drug does not need to be retrieved. The anhydride has a labile bond in the main chain of the polymer. This labile bond then breaks down into two carboxylic acid groups. [Pg.472]

Biocompatible ortho aromatic polyanhydrides, (IV), prepared by Uhrich [5] were used in drug delivery systems and as scaffolding implants for tissue reconstruction. [Pg.64]

Polyanhydrides degrade primarily by surface erosion and possess excellent in vivo compatibility. In 1996 the FDA approved a polyanhydride-based drug delivery system to the brain of chemotherapeutic agent BCNU, which is currently being manufactured by Guilford Pharmaceutical, Inc. [Pg.1643]

Several other biodegradable, biocompatible, injectable polymers are being investigated for drug delivery systems. They include polyvinyl alcohol, block copolymer of PLA-PEG, polycyanoacrylate, polyanhydrides, cellulose, alginate, collagen, gelatin, albumin, starches, dextrans, hyaluronic acid and its derivatives, and hydroxyapatite. ... [Pg.1644]

Chasin, M., et al. Polyanhydrides as drug delivery systems, in M. Chasin and R. Langer, Biodegradable Polymers as Drug Delivery Systems. New York Marcel Dekker, 1990. [Pg.345]

Chasin M, Domb A, Ron E. Polyanhydrides as drug delivery systems. In Chasin M, Danger R, eds. Biodegradable... [Pg.369]

Mathiowitz, E., Langer, R. Polyanhydride microspheres as drug delivery systems. In Microeapsules and Nanoparticles in Medicine and Pharmacology, Donbrow, M., Ed. CRC Boea Raton, FL, 1992 pp. 99-123. [Pg.914]

M. Chasin, A. Domb, E. Ron, E. Mathiowitz, K. Leong, C. Laurencin, H. Brem, B. Grossman, R. Langer, Polyanhydrides as dmg delivery systems, in Biodegradable Polymers As Drug Delivery Systems, edited by M. Chasin, R. Langer (Marcel Dekker, New York, 1990) pp 43-70. [Pg.950]

Synthetic polymers have recently been examined for use in drug delivery systems. Polyesters, polyurethanes and polyanhydrides are among some of these synthetic polymers [3]. [Pg.294]

See other pages where Polyanhydrides drug delivery systems is mentioned: [Pg.43]    [Pg.44]    [Pg.45]    [Pg.47]    [Pg.49]    [Pg.51]    [Pg.53]    [Pg.55]    [Pg.57]    [Pg.59]    [Pg.61]    [Pg.63]    [Pg.65]    [Pg.67]    [Pg.69]    [Pg.274]    [Pg.90]    [Pg.103]    [Pg.108]    [Pg.376]    [Pg.89]    [Pg.284]    [Pg.2253]    [Pg.2257]    [Pg.12]    [Pg.15]    [Pg.410]    [Pg.370]    [Pg.263]    [Pg.129]    [Pg.153]    [Pg.1363]    [Pg.334]    [Pg.83]    [Pg.222]    [Pg.272]    [Pg.273]   
See also in sourсe #XX -- [ Pg.61 ]

See also in sourсe #XX -- [ Pg.61 ]



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