Drug delivery nanocarriers used

The same group reported the simultaneous radiolabeling (with DOTA-anchored 4Cu) and fluorescence studies, coupled with biodistribution in vivo and in vitro (92). It is believed that appropriately functionalized SWNTs can efficiently reach tumor tissues in mice with no apparent toxicity (159). Furthermore, water-solubilised carbon nanotubes are nontoxic when taken up by cells even in high concentration (92). These studies have been complemented by the recent PET imaging of water-soluble 86Y labelled carbon nanotubes in vivo (mice) (160,161), to explore the potential usefulness of carbon nanocarriers as scaffolds for drug delivery. The tissue biodistribution and pharmacokinetics of model DOTA functionalized nanotubes have been explored in vivo (mouse model). MicroPET images indicated accumulation of activity mainly in the kidney, liver, spleen, and to a much less... 

This section highlights advances in the use of polymer-based carriers in drug delivery. It shows how utilisation of polymers in a smart fashion could result in multiple responses at the desired point of action. The criteria and manufacturing requirements of a polymer-based nanocarrier are described in detail. Progress and innovations in drug-delivery technologies are also recounted. 

The development of a drug delivery syston that can be used for the posterior segment of the eye and that involves nanocarriers to overcome the issue of frequent intravitreal administration has received considerable attention. 

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