Thermo-responsive drug carriers

Chung, J. E., Yokoyama, M., Aoyagi, T., Sakurai, Y., and Okano, T. Effect of molecular architecture of hydrophobically modified poly(A-isopropylacrylamide) on the formation of thermo-responsive core-shell micellar drug carriers. J. Contr. Rel, 1997, 53, 119-130. 

Cammas S, Suzuki K, Sone C, Sakurai Y, Kataoka K, Okano T. Thermo-responsive polymer nanoparticles with a core-shell micelle structure as site-specific drug carriers. 

Chen, G., Amajjahe, S. and Stenzel, M. H. (2009) Synthesis of thiol-finked neogly-copolymers and thermo-responsive glycomiceUes as potential drug carrier . Chemical Communications, 1198-1200. 

Chen G, Amajjahe S, Stenzel MH (2009) Synthesis of thiol-linked neoglycopolymers and thermo-responsive glycomicelles as potential drug carrier. Chem Commun (10) 1198-1200... 

Wu, X, Wang, Z., Zhu, D, Zong, S., Yang, L., Zhong, Y., and Cui, Y. (2013) pH and thermo dual-stimuli-responsive drug carrier based on mesoporous silica nanoparticles encapsulated in a copolymer-lipid bilayer. ACS Appl. Mater. Interfaces, 5 (21), 10895-10903. 

EDC was employed for the preparation of GL hydrogel for the drug release to the corneal endothelium with high biocompatibility and efficacy (Lai et al., 2013), and for the release of Growth Factors (Reno et al., 2012 Ishida et al., 2010). In a work by Chen et al. (2011), EDC and iV-hydroxysuccinimide (NHS) were used as crosslinkers for the preparation of thermosensitive hydrogels composed of hyaluronic acid (HA) and GL. The thermo-responsivity was conferred by the grafting of NIPAAm onto HA, while ECD/NHS was used for the subsequent linkage to GL chains. The whole system was proposed as carriers for the cisplatin delivery to the bladder. 

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