Drug and Therapeutics Bulletin

Consumers Association. Prescribing unhcensed drugs or using drugs for unhcensed indications. Drug and Therapeutics Bulletin 1992 30 97-9. 

Anon (2005) H, pylori eradication in NSAID-associated ulcers. Drugs and Therapeutics Bulletin 43 37-40. 

Anon (2006) Omalizumab for severe asthma Drug and Therapeutics Bulletin 44 86-88. 

Anon (1999) Cough medications in children. Drugs and Therapeutics Bulletin 37 19-21. 

European Medicines Evaluation Agency and the New Licensing Arrangements, Drug and Therapeutics Bulletin, go see also Brown, No Place for Secrecy, 3-4. 

Anon, 1991b. Local apphcations to wounds — II dressings for wounds and ulcers. Drug and Therapeutics Bulletin 29 (25), 97—100. 

Drug and Therapeutics Bulletin (1976) Dantrolene sodium (Dantrium). 14,61. 

Besides conceptual progresses, the formal evolution in the concept of medicines was based on the radical transformation of the nature of medicines. One of the theorists of this trend, Charles Louis Cadet de Gassicourt, reported in the inaugural issue of the Bulletin de Pharmacie (1809) that the use of complex preparations had to be withdrawn in favor of pure substances. Pharmacist and physicians had, first, to classify drugs and their use. This trend was much more convenient with pure substances. Between 1815 and 1820, the first active principles were isolated from plants. At that time, a new era in pharmaceutical chemistry opened. Hereafter, drug activity would not depend on the quality of extracts or tinctures and their inherent variability in active principles. The only variability acceptable in therapeutics would be the patient himself. 

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