Drugs action, mechanism

Scheme 4 Drug action mechanisms of thermoresponsive polymeric micelles.

Colatsky TJ, Follmer CH, Starmer CF (1990) Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias. Circulation 82 2235-2242... 

Receptor Concept of Drug Action Mechanisms 1.5.1. Historical Development... 

The main goal of the Encyclopedia is to provide up-to-date information on the molecular mechanisms of drug action. Leading experts in the field have provided 159 essays, which form the core structure of this publication. 

Coulson C.J. (1994) Molecular Mechanisms of Drug Action. London Taylor Francis. 

Appel, J.B. White, F.J. and Holohean, A.M. Analyzing mechanisms of hallucinogenic drug action with drug discrimination procedures. Neurosci Biobehav Rev 6 529-536, 1982. 

Many measurements in pharmacology rely on a chain of events following receptor activation to produce a measurable response — for example, contraction of the smooth muscle of a piece of guinea-pig ileum in response to muscarinic receptor activation by acetylcholine. This means that the relationship between receptor occupancy and response is likely to be complex, and mechanisms of drug action in such systems are often difficult to define. 

Ross, E.M., Pharmacodynamics mechanisms of drug action and the relationship between drug concentration and effect, in Goodman and Gilman s The Pharmacological Basis of Therapeutics, 9th ed., Hardman, J.G. and Limbird, L.E., Eds., McGraw-Hill, New York, 1996, chap. 2. 

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