Drotrecogin alfa Aspirin

ASPIRIN DROTRECOGIN ALFA t risk of bleeding Additive effect on clotting mechanism drotrecogin alfa has antithrombotic and fibrinolytic effects Careful risk-benefit analysis should be undertaken if drotrecogin alfa is given within 7 days of aspirin... 

Drotrecogin alfa should be used with care in patients receiving heparin, thrombolytic drugs, oral anticoagulants, glycoprotein Ilb-IIIa inhibitors, and aspirin or other antiplatelet drugs (6). 

The manufacturers of drotrecogin alfa contraindicate its use with therapeutic doses of heparin (15 units/kg/hour or more), but state that prophylactic heparin doses may be used concurrently. They also say that the risk benefit ratio of drotrecogin alfa should be carefully assessed in patients who have received thrombol i ics in the last 3 days, or oral anticoagulants, aspirin or platelet inhibitors within 7 days. 

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