Drosophila melanogaster level

Methylmercury compounds have induced abnormal sex chromosomes in the fruit fly (Drosophila melanogaster) (NAS 1978 Khera 1979). Earthworms (Eisenia foetida) exposed to soil containing methylmercury concentrations of 5.0 mg Hg/kg — typical of soil Hg levels near chloralkali plants — showed a significant reduction in the number of segments regenerated after 12 weeks, and contained... 

In Drosophila melanogaster, deficiency of CuZnSOD decreases hfe span and accelerates aging [249,250] while simultaneous overexpression of CuZnSOD plus CAT [251] or overexpression of CuZnSOD or MnSOD alone increases hfe span [252,253,254]. Lowered (down to 14%) levels of CAT have no effect [255] but knockout of CAT decreases hfe span [256] overexpression has no positive effect on the longevity of Drosophila [254,256,257]. 

Connolly, K., Tunnicliff, G. and Rick, J. T. (1971) The effects of gamma-hydroxybutyric acid on spontaneous locomotor activity and dopamine level in a selected strain of Drosophila melanogaster. Comp. Biochem. Physiol., 408, 321-326. 

Fig. 25.1.1. Chemical structures of 20-hydroxyecdysone (20E 1 R] = OH), the first bisacylhydrazine found to have an ecdysone agonist effect in insect assays (2), and the first bisacylhydrazine (RH-5849 3) well characterized for its ecdysone effects at cellular and whole insect level, as well as binding to Drosophila melanogaster ceW extracts containing ecdysteroid receptor complexes. Numbers on the 20E structure represent the carbon-numbering system.

Aquadro, C.F., K.M. Lado and W.A. Noon 1988 The Rosy region of Drosophila melanogaster and Drosophila simulans. I. Contrasting levels of naturally occurring DNA restriction map variation and divergence. Genetics. 119 875-888. 

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