Indinavir Dronabinol

The effects of smoked marijuana (3.95% tetrahydrocannabinol up to three cigarettes per day) and oral dronabinol (2.5 mg tds) on the pharmacokinetics of indinavir 800 mg 8-hourly (n = 28) have been evaluated in a randomized, placebo-controlled study in HIV-infected patients (148). On day 14, marijuana reduced the 8-hour AUC of indinavir by 15%, the Cmax by 14%, and the Cm n... 

The short-term use of cannabis cigarettes or dronabinol did not appear to adversely affect indinavir or nelfinavir levels or viral loads in HIV-positive patients. 

In 9 HIV-positive patients on a stable regimen containing indinavir (mostly 800 mg every 8 hours), smoking a cannabis cigarette (3.95% tetrahydrocannabinol) three times a day before meals for 14 days resulted in a median 14% decrease in AUC and maximum level and a 34% decrease in minimum indinavir level. However, only the change in maximum level was statistically significant. Similarly, dronabinol 2.5 mg three times daily for 14 days had no significant effect on indinavir pharmacokinetics. ... 

Short-term use of cannabis cigarettes or dronabinol does not appear to have any important effect on levels of indinavir or nelfinavir, nor on markers of HIV infection. 

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