Drivers for Performing Hantzsch Syntheses in Micro Reactors

1 Drivers for Performing Hantzsch Syntheses in Micro Reactors 

The Hantzsch synthesis was primarily chosen to evaluate the potential of a micro-mixing-tee chip reactor for carrying out reactions above room temperature (e.g. 

70 °C) [9, 10]. It is said to be the first example of a heated organic reaction performed in a glass chip reactor imder electroosmohc flow (EOF) control [10] (for EOF see [14]). The performance of this reactor for room-temperatare reactions such as the Wittig reaction and Suzuki coupling was demonstrated before. 

In a wider sense, the Hantzsch synthesis is a further example for evaluating the potenhal of microfluidic systems for high-throughput screening [9]. 

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