Drivers for Performing Conjugated Alkene Hydrogenation in Micro Reactors

1 Drivers for Performing Conjugated Alkene Hydrogenation in Micro Reactors 

Despite affecting conversion, mass transfer is known to impact enantio- and regioselectivity for many reactions [63]. For this reason, conventional micro-titration apparatus, typically employed in combinatorial chemistry of single-phase reactions, also often suffer from insufficient mixing when dealing with multi-phases [63, 66]. 

The hydrogenation of a cinnamate was also investigated as a first step to determine kinetics and finally to come to a quantitative determination of kinetic models and parameters in asymmetric catalysis [64]. The enantiomeric excess of enantioselective catalytic hydrogenations is known to be dependent on pressure, chiral additives and mixing. Such dependences are often due to kinetics, demanding appropriate studies. 

In another investigation, process development and optimization studies were undertaken [67]. In the framework of a study conducted as contract research for 

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