Drivers for Performing Aromatic Fluorination in Micro Reactors

1 Drivers for Performing Aromatic Fluorination in Micro Reactors 

Aromatic fluorination certainly is one of the best candidate reactions for micro reactors. Fluorinated compounds are of high industrial interest. For instance, they find wide application as pharmaceuticals, dyes, liquid crystals and crop-protection agents [3,13,16, 38] about every third drug contains a fluorine moiety. The introduction of fluorine moieties in molecules has unique effects on biological activity (see original citations in [16]). 

So far, complex synthesis routes have been followed to realize these compounds, leading to a reduction in selectivity and being associated with high waste generation (see the discussion on this topic in [GL 1, below]). A direct route using the elemental material would thus be highly favorable. 

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