Draggability

A binding site should be capable of burying large portions of a small molecule ligand, 

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Currently there are drugs for only a fraction of the draggable targets present in the human genome. 

Hopkins AL, Groom CR (2002) The draggable genome. Nat Rev Drag Discov 1 727-730... 

The seven chapters of this volume describe recent progress towards drugs acting at a range of draggable targets. One chapter addresses kinases, one covers an ion channel, two feature proteases and three of the chapters cover G-protein coupled receptors, which have historically perhaps been the most fruitful area for medicinal chemists. 

The draggability of enzymes as targets reflects the evolution of enzyme structure to efficiently perform catalysis of chemical reactions, as discussed in the following section. 

P.J. Hajduk, J.R. Huth and S.W. Fesik, Draggability indices for protein targets derived from NMR-based screening data, J. Med. Chem., 48, 2518-2525 (2005). 

Winum J-Y, Rami M, Scozzafava A, Montero J-L, Supuran C (2008) Carbonic anhydrase IX a new draggable target for the design of antitumor agents. Med Res Rev 28 445 -63... 

Sugiyama, Y. (2005) Draggability selecting optimized drag candidates. Drug Discov. Today, 10, 1577-1579. 

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