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Drag polymorphism

Single-base substitutions, which affect the amino acid sequence of proteins and lead to altered protein function, are the most frequent type of polymorphisms associated with many disease phenotypes as well as with variation in drag response... [Pg.501]

The differences in the frequencies of certain polymorphisms are relevant because of the potential to fragment markets for pharmaceuticals. Just as pharmacogenomics will enable physicians to tailor drag therapy to suit an individual, so will... [Pg.521]

Bertilsson, L., "Geographical/Interracial Differences in Polymorphic Drag Oxidation Current State of Knowledge of Cytochromes P450 (CYP) 2D6 and 2C19," Clin. Pharmacokinet., 29, 192-209 (1995). [Pg.160]

Bosch, T.M., Meijerman, I., Beijnen, J.H., et al. (2006) Genetic polymorphisms of drug-metabolising enzymes and drag transporters in the chemotherapeutic treatment of cancer. Clin. Pharmacokinet. 45, 253-285. [Pg.72]

The significance of polymorphism in the pharmaceutical industry lies in the fact that polymorphs can exhibit differential solubility, dissolution rate, chemical reactivity, melting point, chemical stability or bioavailability, among others. Such differences can have considerable impact on a drag s effectiveness. Usually, only one polymorph is stable at a given temperature, the others being metastable and evolving to the stable phase... [Pg.482]

Torchilin VP (2006) Polymorphic micelles as pharmaceutical carriers. Polym Drag DeUv 111-130... [Pg.143]

See other pages where Drag polymorphism is mentioned: [Pg.4]    [Pg.114]    [Pg.923]    [Pg.925]    [Pg.951]    [Pg.951]    [Pg.951]    [Pg.4]    [Pg.59]    [Pg.63]    [Pg.63]    [Pg.143]    [Pg.179]    [Pg.192]    [Pg.194]    [Pg.267]    [Pg.339]    [Pg.490]    [Pg.494]    [Pg.515]    [Pg.523]    [Pg.523]    [Pg.22]    [Pg.42]    [Pg.46]    [Pg.50]    [Pg.50]    [Pg.51]    [Pg.51]    [Pg.54]    [Pg.55]    [Pg.57]    [Pg.64]    [Pg.159]    [Pg.213]    [Pg.216]    [Pg.223]    [Pg.272]    [Pg.274]    [Pg.307]    [Pg.361]    [Pg.494]    [Pg.495]    [Pg.253]    [Pg.9]   
See also in sourсe #XX -- [ Pg.365 ]



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