Dr adhesins

Berger, C. N., Billker, O., Meyer, T. F., Servin, A. L., and Kansau, 1. (2004). Differential recognition of members of the carcinoembryonic antigen family by Afa/Dr adhesins of diffusely adhering Escherichia coli (Afa/Dr DAEC). Mol. Microbiol. 52, 963-983. 

At least some adhesins bind to more than one receptor. Intimin might not only bind to Tir but also to pi containing integrins as well as to nucleolin [65], The Dr adhesin recognizes not just the short consensus repeat domain as all members of the Dr family of adhesins but also type IV collagen, which is a critical step in renal persistence [66],... 

Anderson KL, BiUington J, Pettigrew D et al. (2004) An atomic resolution model for assembly, architecture, and function of the Dr adhesins. Mol Cell 15 647-657... 

Selvarangan R, Goluszko P, Singhal J et al. (2004) Interaction of Dr adhesin with collagen type IV is a critical step in Escherichia coli renal persistence. Infect Immun 72 4827 1835... 

Fimbrial adhesins may be visualized by electron microscopy. However, the processing for analysis by electron microscopy might cause alterations of the specimens, e.g. by dehydration. This might result in the collapse of certain fimbriae. Therefore, despite no fimbriae are visible by electron microscopy the afimbrial adhesins of the Dr family, e.g. AfaE of diarrheagenic and uropathogenic E. coli in fact assemble... 

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