Malaria doxycycline for

Some in vitro studies have demonstrated that azithromycin is active against chloroquine-sensitive and -resistant strains of Plasmodium falciparum [285]. A trial using daily azithromycin at a dose of 250 mg as a malaria prophylaxis in volunteers has shown azithromycin to be protective against P. falciparum challenge [286,287]. A randomized, placebo-controlled, double-blind study of malaria prophylaxis compared two regimens of azithromycin versus daily doxycycline for a period of 10 weeks in western Kenya [287]. Both regimens with daily azithromycin and doxycycline provided effective prophylaxis of falciparum malaria in this trial. A potential advantage of azithromycin over doxycycline for malaria prophylaxis is... 

Kotecka B, Edstein M D, Rieckmann K H (1996). Chloroquine bioassay of plasma specimens obtained from soldiers on cholo quine plus doxycycline for malaria priphy-laxis. Int. J. Parasitol. 26 1325-1329. 

Skin Drug rash with eosinophilia and systemic symptoms (DRESS) is relatively common in patients taking minocycline, but seems to be much less so in patients taking doxycychne. However, a report has appeared in a 25-year-old woman of African origin who had been taking doxycycline for malaria prophylaxis for 3 weeks [122 ]. 

Nervous system Benign intracranial hypertension has been reported in a 26-year-old woman who was taking doxycycline for malaria prophylaxis [134 ]. 

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