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Doxorubicin tumor-activated prodrug

Several ADEPT systems that are beyond the scope of this chapter have been studied extensively and are the subject of many reviews.15,92-93 One of the most widely cited ADEPT systems employs a glucouronidase (GUS)-monoclonal antibody conjugate that activates a doxorubicin-glu-curonide prodrug. Studies have shown that there is a substantial therapeutic benefit, a higher level of drug in tumor tissue when compared... [Pg.391]

Indeed, when compared with standard chemotherapy using doxorubicin, the doxorubicin concentrations generated by fusion protein-mediated prodrug activation resulted in 4-12 fold higher doxorubicn concentrations in the tumor and to 2.5 fold lower doxorubicin concentrations in normal tissues (69). [Pg.177]

See other pages where Doxorubicin tumor-activated prodrug is mentioned: [Pg.371]    [Pg.279]    [Pg.160]    [Pg.122]    [Pg.280]    [Pg.281]    [Pg.684]    [Pg.216]    [Pg.234]    [Pg.157]    [Pg.157]    [Pg.177]    [Pg.274]    [Pg.331]    [Pg.1153]    [Pg.100]    [Pg.601]    [Pg.602]    [Pg.247]    [Pg.332]    [Pg.78]   
See also in sourсe #XX -- [ Pg.5 , Pg.88 ]



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Doxorubicin

Doxorubicine

Prodrug

Prodrugs activation

Tumor-activated prodrugs

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