Radiotherapy doxorubicin

Doxorubicin—monitor cumulative dose for cardiac toxicity (not to exceed 550 mg/M2 or 450 mg/M2 with prior chest radiotherapy) vesicant—avoid extravasation use 50% for bilirubin 1.5-3.0 use 25% for bilirubin > 3.0... 

The approach to PNET is similar to that described for osteosarcomas, although the chosen cytotoxic agents are different and radiotherapy plays a more important role. Treatment should be started with chemotherapy, usually comprising a combination of agents such as doxorubicin, VP-16, ifosfamide or cyclophosphamide, actinomycin-D and vincristine. After an optimal local response has been obtained, either surgery or local radiotherapy is applied depending on the site of the disease and the applicability of the technique. Sometimes a combination of both is applied. After optimal local treatment. 

Habib MJ, Asker AF. Photostabilization of doxorubicin hydrochloride with radioprotective and photoprotective agents potential mechanism for enhancing chemotherapy during radiotherapy. J Parenter Sci Technol 1989 43 259-261. 

Acute lymphocytic leukemia Induction vincristine plus prednisone. Remission maintenance mercaptopurine, methotrexate, and cyclophosphamide in various combinations Asparaginase, daunorubicin, carmustine, doxorubicin, cytarabine, allopurinol,1 craniospinal radiotherapy... 

Wilms tumor Vincristine plus dactinomycin after surgery and radiotherapy Methotrexate, cyclophosphamide, doxorubicin... 

---