Double stage convergent method

Compared to conventional convergent synthesis, the two-stage method promises fast access to higher-generation monodisperse dendrimers, combined with a jump in terminal functionalities, since the surface functionalities of the hypercore are subject to less steric hindrance than in the case of simple non-dendritic core building blocks of conventional convergent synthesis. Moreover, this approach permits the formation of dendrimers with different inner and outer branching units (layer-block dendrimers) [10,13]. 

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Fig. 2.4 Double-stage convergent method (C=coupling group, F=functional group)...

Recently, new methods such as orthogonal synthesis, double-stage convergent method, double-exponential method, hypermonomer method, and click chemistry have been disclosed for synthesis of dendrimers [5]. 

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