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Double Mutant Cycles - Quantifying Weak Interactions

4 Double Mutant Cycles - Quantifying Weak interactions [Pg.615]

Cockroft, S. L. and Hunter, C. A., Chemical double-mutant cycles dissecting non-covalent interactions , Chem. Soc. Rev. 2007, 36, 172-188. [Pg.615]

The secondary interactions must be additive functions of the mutations [Pg.615]

The double mutant serves as the reference state and so the individual mutations should be noninteracting. [Pg.615]

Each member of the cycle should have the same conformation and any structural changes must be the same on both sides of the cycle. [Pg.615]




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