Dose-response reaction, definition

The prevalence or incidence rates of ICM-induced hypersensitivity show great variability in the literature [5-17]. The reason for this phenomenon is unclear. The study design/setting, the use of different ICM, different doses in different patient groups, and the experience of involved medical personnel may be responsible for this phenomenon. Furthermore, the definition of adverse events differs from paper to paper. While some authors report on prevalence rate of adverse ICM reactions in general, others focus on hypersensitivity reactions, and found prevalences of 0.7-3.1% [16,18]. 

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