Dose limits effect curves

FIGURE 6.14. Experimental uptake curves of n-pentane in Linde 5A crystals (3.6 jtim) showing effect of sample size. The uptake curve for the thin bed (IS-mg sample) is dose to the limiting isothermal curve, but as the depth of the sample bed is increased the deviations become increasingly pronounced. (From ref. 20, with permission.) ... 

To.xicity values for carcinogenic effects can be e.xprcsscd in several ways. The slope factor is usually, but not always, the upper 95th percent confidence limit of the slope of the dose-response curve and is e.xprcsscd as (mg/kg-day). If the extrapolation model selected is the linearized multistage model, this value is also known as the ql. That is ... 

FIGURE 6.1 Effects of antagonists on agonist dose-response curves, (a) Surmountable antagonism with no diminution of maxima and no limiting antagonism (competitive antagonists). 

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